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The Department of Food Technology and Biotechnology was founded in 2005.

The Department offers a variety of programs in education at several levels:

  1. First degree of academic and professional study that lasts four years leading to the title of Bachelor's Degree in Food Products Technology.
  2. Second degree of academic study lasting two years leading to the title of Master in Food Technology and specialized academic and professional studies lasting one year leading to the degree Engineer in Technology of Fats, Ester Oils and Perfumery-Cosmetic Products and Engineer in Food Products Biotechnology).
  3. Third degree of academic study – PhD (in Chemical Technology).

Academic staff of the department comprises two professors, five associate professors and one research worker. Currently the Department is headed by Doctor of Science (Chemistry), Prof., member of Academy of Engineering Sciences Sergei V. Makarov. The researches of the workgroup of Prof. Sergei Makarov is centred around the kinetics of chemical reactions catalyzed by metallocomplexes of porphyrins and related compounds as well as chemistry of thiourea oxides, sulfoxylate and nitrite. He is a Member of Editorial Board of Journal of Coordination Chemistry and Member of Editorial Board of Acta Metallomica

Selected publications of Sergei V. Makarov:

  • E.A. Vlasova, N. Hessenauer-Ilicheva, D.S.Salnikov, E.V.Kudrik, S.V.Makarov, R. van Eldik, Kinetics and mechanism of the Co(II)-assisted oxidation of L-ascorbic acid by dioxygen and nitrite in aqueous solution, Dalton Trans., 2009, 10541-10549.
  • A.S.Pogorelova, S.V.Makarov, E.S.Ageeva, R. Silaghi-Dumitrescu, Cobalt Tetrasulfophthalocyanine as a Catalyst of the Reduction of Nitrite with Thiourea Dioxide, Russ. J. Phys. Chem.A, 2009, v. 83, N 12, 2050-2053.
  • R. Silaghi-Dumitrescu, S.V. Makarov, Hydrocarbon Oxygenation by Metal Nitrite Adducts: Theoretical Comparison with Ferryl-Based Oxygenation Agents, Eur. J. Inorg. Chem., 2010, 1129-1132.
  • A. Mot, Z. Kis, D.A. Svistunenko, G. Damian, R. Silaghi-Dumitrescu, S.V.Makarov, "Super-reduced" iron under physiologically relevant conditions, Dalton Trans., 2010, V.39, 1464-1466.
  • Z.Kis, S.V.Makarov, R. Silaghi-Dumitrescu, Computational investigations on the electronic structure and reactivity of thiourea dioxide: sulfoxylate formation, tautomerism and dioxygen liberation, J. Sulfur Chem., 2010, v.31, N1, 27-39.
  • S.V.Makarov, D.S.Salnikov, A.S.Pogorelova, Acid-Base Properties and Stability of Sulfoxylic Acid in Aqueous Solutions, Russ. J. Inorg. Chem., 2010, v. 55, N 2, 301-304.
  • A.S.Pogorelova, E.A.Vlasova, M.N. Malinkina, S.V. Makarov, O.I. Koifman, The Interaction of Cobalt Tetrasulfophthalocyanine and Octasulfophenyltetrapyrazinoporphyrazine with Ascorbic Acid, Russ. J. Phys. Chem.A, 2010, v. 84, N 4, 617-623.
  • E.A.Vlasova, S.V. Makarov, M.N. Malinkina, The Kinetics of Nitrite Reduction by Thiourea Dioxide in the Presence of Cobalt Octasulfophenyltetrapyrazinoporphyrazine, Russ. J. Phys. Chem. A, 2010, v. 84, N 4, 573-577.
  • S.V.Makarov, D.S.Salnikov, A.S.Pogorelova, Z. Kis, R. Silaghi-Dumitrescu, A new route to carbon monoxide adducts of heme proteins, J.Porphyrins and Phthalocyanines, 2008; 12, N 10, 1096 - 1099.
  • E.V.Kudrik, V.N.Shishkin, S.V.Makarov, M.V.Volodarskii, The interaction of iron octasulfophenyltetrapyrazinoporphyrazinate with the hydroxide-ion and cysteine, Russ. J. Phys.Chem.A, 2007, vol.81, N 6, p.901.
  • E.V.Kudrik, S.V.Makarov, A. Zahl, R.van Eldik, Kinetics and mechanism of the iron phthalocyanine catalyzed reduction of nitrite by dithionite and sulfoxylate in aqueous solutions, Inorg. Chem., 2005, vol. 44, N 18, p. 6470.
  • E.V.Kudrik, S.V.Makarov, R.van Eldik, E.V.Naidenko, Reactions of methyl viologen and nitrite with thiourea dioxide. New opportunities for an old reductant, J. Chem. Soc., Dalton Trans., 2002, N 22, p. 4074.
  • S.V.Makarov, Recent trends in the chemistry of sulfur-containing reducing agents, Russ. Chem. Rev., 2001, vol. 70, N 10, p. 885.
  • D.S.Salnikov, R.Silaghi-Dumitrescu, S.V.Makarov, R.van Eldik, G.Boss, Cobalamin reduction by dithionite. Evidence for formation of a six-coordinate cobalamin (II) complex, Dalton Trans., 2011, v. 40, 9831-9834.
  • R. Silaghi-Dumitrescu, S.V.Makarov, M.M.Uta I.A.Dereven’kov, P.A.Stuzhin, Redox non-innocence of a nitride bridge in a methane-activating dimer of iron phthalocyanine, New J.Chem., 2011, v. 35, N 5, 1140-1145.
  • I.A.Dereven’kov, S.S.Ivanova, E.V.Kudrik, S.V.Makarov, A.S.Makarova, P.A.Stuzhin,        Comparative Study of Reactions between m-Nitrido- or m-Oxo-Bridged Iron Tetrasulfophthalocyanines and Sulfur-Containing Reductants, J.Serb.Chem.Soc, 2013, 78, 1513 - 1530.
  • M.Surducan, D.Lup, A.Lupan, S.V.Makarov, R.Silaghi-Dumitrescu, Electromerism and linkage isomerism in biologically-relevant Fe-SO complexes, J.Inorg.Biochem., 2013, 118, 13-20.
  • D.S.Salnikov, I.A.Dereven’kov, E.N.Artushina, S.V.Makarov, Interaction of cyanocobalamin with sulfur-containing reductants in aqueous solutions, Zh.Fiz.Chim. (Russ.J.Phys.Chem.), 2013, 87, 52-56 (in Russian).
  • D.S.Salnikov, I.A.Dereven’kov,  S.V.Makarov, A.Lupan, M.Surducan, R.Silaghi-Dumitrescu, Kinetics of reduction of cobalamin by sulfoxylate in aqueous solutions, Rev.Roum.Chim., 2012, 57, 353-359.
  • A.C.Mot, S.A.Syrbu, S.V.Makarov, G.Damian, R.Silaghi-Dumitrescu, Axial ligation in water-soluble porphyrinates: contrasts between EPR and UV-Vis, Inorg.Chem.Commun., 2012, 18, 1-3.
  • P.A.Stuzhin, S.S.Ivanova, I.A.Dereven’kov, S.V.Makarov, R.Silaghi-Dumitrescu, H.Homborg, First Water-Soluble μ-Nitrido Dimer of Iron Phthalocyanine, Macroheterocycles, 2012, 5, 175-177.
  • I.A. Dereven’kov, D.S. Salnikov, S.V. Makarov, M. Surducan, R. Silaghi-Dumitrescu, G.R. Boss, Comparative study of reaction of cobalamin and cobinamide with thiocyanate, J. Inorg. Biochem., 2013, 125, 32.
  • I.A.Dereven'kov, D.S.Salnikov, S.V.Makarov, G.R.Boss, O.I.Koifman, KInetics and mechanism of oxidation of super-reduced cobalamin and cobinamide species by thiosulfate, sulfite and dithionite, Dalton Trans., 2013, 15307 - 15316.
  • S.V.Makarov, R.Silaghi-Dumitrescu, Sodium dithionite and its relatives: past and present, J.Sulfur Chem., 2013, 34, 444.
  • Gy. Cseko, Y. Hu, Y. Song, R.T. Kegl, Q. Gao, S. V. Makarov, A.K. Horvath, Kinetic evidence of tautomerism of thiourea dioxide in aqueous acidic solutions. Eur. J. Inorg. Chem., 2014, 11, 1875.
  • D.S.Salnikov, P.N.Kucherenko, I.A.Dereven'kov, S.V.Makarov, R. van Eldik, Kinetics and mechanism of the reaction of hydrogen sulfide with cobalamin in aqueous solution, Eur. J. Inorg. Chem., 2014, 852.
  • M. Surducan, S.V. Makarov, R. Silaghi-Dumitrescu, Redox and linkage isomerism with ligands relevant to oxidative and nitrosative stress in cobalamin, Polyhedron, 2014, 78, 72.
  • D.S.Salnikov, S.V.Makarov, R. van Eldik, P.N.Kucherenko, G.R. Boss, Kinetics and mechanism of the reaction of hydrogen sulfide with diaquacobinamide in aqueous solution, Eur. J. Inorg. Chem., 2014, 4123 - 4133.
  • R.R.Borodulin, I.A.Dereven’kov, D.Sh Burbaev, S.V.Makarov, V.D.Mikoyan, V.A.Serezhnikov, L.N.Kubrina, I.Ivanovic-Burmazovic, A.F.Vanin, Redox activities of mono- and binuclear forms of low-molecular and protein-bound dinitrosyl iron complexes with thiol-containing ligands, Nitric oxide, 2014, 40, 100.
  • A.S.Makarova, E.V.Kudrik, S.V.Makarov, O.I. Koifman, Stability and catalytic properties of μ-oxo and μ-nitrido dimeric iron tetrasulfophthalocyanines in the oxidation of Orange II by tert-butylhydroperoxide, J. Porphyrins Phthalocyanines, 2014, 18, 604.
  • A.A.Atta, S.V.Makarov, A.F.Vanin, R.Silaghi-Dumitrescu, Asymmetry within the Fe(NO)2 moiety of dithiolate dinitrosyl iron complexes, Inorg.Chim. Acta, 2014, 418, 42.
  • S. V. Makarov, A. Horvath, R. Silaghi-Dumitrescu, Q. Gao, Recent Developments in the Chemistry of Thiourea Oxides, Chem. Eur. J., 2014, 20, 14164 - 14176.
  • S.V.Makarov, A.S.Makarova, R. Silaghi-Dumitrescu, Sulfoxylic and Thiosulfurous Acids and their Dialkoxy Derivatives, Patai’s Functional Groups, Peroxides, vol. 3, Eds J. Liebman and A. Greer, Wiley, 2014
  • Vlasova E. A., Shalunova N.K., Makarova A. S., Kudrik E.V., Makarov S.V., “Metal-organic frameworks based on terephthalic acid: Sorbents of organic dyes”, Russ J.  Appl. Chem, 2014, v. 87, N 8, pp. 1065-1069.
  • E.A. Vlasova, E. V. Naidenko, E. V. Kudrik, A. S. Makarova, S. V. Makarov, Efficient synthesis of aluminum- and zinc-containing metal-organic frameworks, Inorg. Materials, 2015, 51, 236-240.
  • Y. Hu, A.K. Horvath, S. Duan, S.V. Makarov, Q. Gao, Mechanism Involving Hydrogen Sulfite Ions, Chlorite Ions, and Hypochlorous Acid as Key Intermediates of the Autocatalytic Chlorine Dioxide-Thiourea Dioxide Reaction, Eur. J. Inorg. Chem., 2015, 2015, 2015, 5011-5020.
  • I. A. Dereven’kov, D.S. Salnikov, R. Silaghi-Dumitrescu, S. V. Makarov, O. I. Koifman, Redox chemistry of cobalamin and its derivatives, Coord. Chem. Rev., 2016, 309, 68-83.
  • E. A. Vlasova, S. Yakimov, E. V. Naidenko, E. V. Kudrik, S. V. Makarov, Application of metal-organic frameworks for purification of vegetable oils, Food Chem., 2016, 2016, 190, 103-109.
  • E. S. Grishina, A. S. Makarova, E. V. Kudrik, S. V. Makarov, O. I. Koifman, Synthesis of the iron phthalocyaninate radical cation μ-nitrido dimer and its interaction with hydrogen peroxide. Russ. J. Phys. Chem. A, 2016, 90, 704-706.
  • I. A. Dereven’kov, T.T.B. Thi, D. S. Salnikov, S. V. Makarov, Effect of amino acids on the interaction between cobalamin (II) and dehydroascorbic acid, Russ. J. Phys. Chem. A, 2016, 90, 596.
  • S.V. Makarov, A. Horvath, R. Silaghi-Dumitrescu, Q. Gao, Sodium Dithionite, Rongalite and Thiourea Oxides: Chemistry and Application, World Scientific, Singapore, 2016
  • T. T. T. Bui, D. S. Salnikov, I. A. Dereven’kov, S. V. Makarov, Kinetics of reactions of aquacobalamin with aspartic and glutamic acids and their amides in water solutions, Russ. J. Phys. Chem. A, 2017, 91, N 4, 658-661.
  • I. A. Dereven’kov, N. I. Shpagilev, L. Valkai, D. S. Salnikov, A. K. Horváth,  S. V. Makarov, Reactions of aquacobalamin and cob(II)alamin with chlorite and chlorine dioxide, J Biol Inorg Chem., 2017, 22, 453 - 459, DOI 10.1007/s00775-016-1417-0.
  • I. A. Dereven'kov, L. Hannibal, M. Durr, D. S. Salnikov, T. T. T. Bui, S. V. Makarov, O. I. Koifman, I. Ivanović-Burmazović, Redox turnover of organometallic B12 cofactors recycles vitamin C: Sulfur assisted reduction of dehydroascorbic acid by cob(II)alamin, J. Organomet. Chem., 2017, 839, 53 - 59, http://dx.doi.org/10.1016/j.jorganchem.2017.01.002
  • L. Xu,  L. Valkai, A. A. Kuznetsova, S. V. Makarov, A. K. Horváth, Kinetics and Mechanism of the Oxidation of Thiourea Dioxide by Iodine in a Slightly Acidic Medium, Inorg. Chem., 2017, 56, 4679 - 4687, DOI: 10.1021/acs.inorgchem.7b00326
  • I. A. Dereven’kov, P. A. Ivlev, D. S. Salnikov, C. Bischin, A. A. A. Attia, R. Silaghi-Dumitrescu  S. V. Makarov, Studies of reaction of tetramethylthiourea with hydrogen peroxide. Evidence of formation of tetramethylthiourea monoxide as a key intermediate of the reaction, J. Sulfur Chem., 2017, 38, 496 - 509 DOI: 10.1080/17415993.2017.1321650
  • I. A. Dereven’kov,  S.V. Makarov, N. I. Shpagilev,  D. S. Salnikov, O. I. Koifman, Studies on reaction of glutathionylcobalamin with hypochlorite. Evidence of protective action of glutathionyl-ligand against corrin modification by hypochlorite, Biometals, 2017, 30, 757 - 764, DOI https://doi.org/10.1007/s10534-017-0044-8
  • I.A.Dereven’kov, A. Yu.Polyakova, S.V.Makarov, Kinetic and mechanistic studies on reaction between aquacobalamin and selenocysteine, Eur. J. Inorg. Chem., 2017, 2017, 4174 - 4179, DOI: 10.1002/ejic.201700973
  • I.A.Dereven'kov, P. A. Ivlev, C. Bischin, D.S. Salnikov, R. Silaghi-Dumitrescu, S.V.Makarov, O.I.Koifman, Comparative studies of reaction of cobalamin(II) and cobinamide (II) with sulfur dioxide, J. Biol. Inorg. Chem., 2017, 22, 969-975.
  • S.V. Makarov, A.A. Kuznetsova, D.S. Salnikov, A.G. Kiseleva, Influence of glycine and monoethanolamine on stability and reducing properties of thiourea dioxide in aqueous solutions, Russ. J. Gen. Chem., 2018, 88, 646
  • I.A. Dereven’kov, L. Hannibal, ·S.V. Makarov, A.S. Makarova, P.A. Molodtsov, O.I. Koifman, Characterization of the complex between native and reduced bovine serum albumin with aquacobalamin and evidence of dual tetrapyrrole binding, J. Biol. Inorg. Chem., 2018, 23, 725-738, https://doi.org/10.1007/s00775-018-1562-8
  • I.A. Derevenkov, S.V. Makarov, T.T. Bui Thi, A.S. Makarova, O.I. Koifman, Studies on the Reduction of Dehydroascorbic Acid by Glutathione in the Presence of Aquahydroxocobinamide, Eur. J. Inorg. Chem., 2018, DOI 10.1002/ejic.201800066
  • D.S. Salnikov, S.V. Makarov, P.A. Ivlev, Comparative studies of redox reactions of aqua- and thiocyanatocobalamin, Zh. Obshch. Khim., 2018, 88, 815-818 (in Russian)
  • P.A. Molodtsov, A.S. Makarova, S.V. Makarov, A.A. Kuznetsova, O.I. Koifman, Interaction of thiourea dioxide and hydrogen peroxide with coumarin, Russ. J.Gen. Chem., 2018, 88, 1086
  • I.A. Dereven'kov, N.I. Shpagilev, S.V. Makarov, Mechanism of the Reaction between Cobalamin(II) and Periodate, Russ. J. Phys. Chem. A, 2018, 92, N11, 2182-2186.
  • I. A. Dereven'kov, L. V. Tsaba, E. A. Pokrovskaya, S. V. Makarov, Studies on the interaction of aquacobalamin with cysteinesulfinic and cysteic acids, hypotaurine and taurine, J. Coord. Chem., 2018., DOI 10.1080/00958972.2018.1515927
  • S.O. Tumakov, I.A. Dereven'kov, D.S. Salnikov, S.V. Makarov, Kinetics of the Reaction between Cobinamide and Izoniazid in Aqueous Solutions, Russ. J. Phys. Chem., 2019, 92, 296-301.
  • Pugina R.A., Denisova E.A., Ivlev P.A., Salnikov D.S., Makarov S.V., Synthesis of vitamin B12 derivatives with sodium hydroxymethanesulfinate, J. Porphyrins Phthalocyanines, 2018, 22, N12, 1092-1098, DOI:10.1142/S1088424618501092
  • I.A. Dereven’kov, S.V. Makarov, Mechanistic studies on the reaction between glutathionylcobalamin and selenocysteine, J. Coord. Chem., 2019, https://doi.org/10.1080/00958972.2019.1570166
  • J. Shao, X. Liu, S. V. Makarov, K. Pei (2019) TDO structure investigation in aqueous solution by TOF-MS, UV, Raman and quantum chemistry calculations, J. Sulfur Chem., 2019, DOI: 10.1080/17415993.2019.1598411
  • D. S. Salnikov, S.V. Makarov, Kinetics and mechanism of the reaction of cyanocobalamin with potassium hydroxide in non-aqueous media, New J. Chem., 2019, DOI: 10.1039/C9NJ01361J
  • J. Shao, X. Liu, S.V. Makarov, K. Pei, The decomposition mechanism for TDO in aqueous solution within 25-95 C temperature range, Chem Phys. Lett, 2019, 731, 136603
  • S.V. Makarov, A.K. Horvath, A.S. Makarova, Reactivity of Small Acids of Sulfur, Molecules 2019, 24 (15), 2768
  • S.V. Makarov, I.A. Dereven'kov, A.S. Makarova, O.I. Koifman, Fundamental and applied aspects of chemistry of vitamin B12: new data, in Functional materials on the base of tetrapyrrolic macroheterocyclic compounds / Ed. O.I. Koifman.- Moscow.: LENAND.- 2019. P. 489-531.
  • I.A. Dereven'kov, L. Hannibal, P.A. Molodtsov, A.M.V. Branzanic, R. Silaghi-Dumitrescu, S.V. Makarov,  Kinetic, spectroscopic and in silico characterization on the first step of the reaction between glutathione and selenite, Inorg. Chim. Acta, 2020, 499, 119215
  • I.A. Dereven'kov, L. Hannibal, S. V. Makarov, P. A. Molodtsov, Catalytic effect of riboflavin on electron transfer from NADH to aquacobalamin, J. Biol. Inorg. Chem. https://doi.org/10.1007/s00775-019-01745-3

Involvement in Funded Projects

Russian Foundation for Basic Research (RFBR)

  • Project 98-03-32802-a “Reactivity of thiourea oxides” (project leader), 1998-1999.
  • Project 07-03-91687-PA_a “Nitrite metallocomplexes of biological relevance: ligand isomerism and redox properties”, Joint project of RFBR and Romanian Academy (project leader), 2007-2008.
  • Project 09-03-11502 Nitrite and nitrate – a new approach (popular paper), 2009
  • Project 11-03-00132a Reactivity of reduced cobalt complexes with tetrapyrroles (project leader), 2011-2013
  • Project 16-03-00162 Thiourea oxides in organic synthesis, 2016-2018 (project leader)
  • Project 19-33-90019 Interaction of thiols and disulfides with sulfinates (project leader)


Collaborative Linkage Grant, 2003-2004 (with prof. R. van Eldik, Erlangen, Germany) (project leader from Russian part).

Russian Ministry of Education

Research Grant “Activation of nitrogen oxides, nitrite and nitrate”, 2003-2004 (project leader).


Two individual grants.
The young staff members have received two grants in the frames of Mikhail Lomonosov Joint Russian-German Program.
 International Cooperations: prof. R. van Eldik (University of Erlangen-Nurnberg, Germany); prof. R. Silaghi-Dumitrescu (Babes-Bolyai University, Cluj-Napoca, Romania); Dr. L. Hannibal (Medical Center, University of Freiburg, Germany), prof. Qingyu Gao (University of Mining and Technology, Xuzhou, China), Dr G.R. Boss (University of California, San-Diego), prof. Attila Horvath (University of Pecs); prof Z.Shao, prof. K.Pei (Zhejiang Sci-Tech University), prof. A. Kornath (Ludwig-Maximilians University, Munich)

Translation of books from English into Russian

  • J.L.Sessler, P.A.Gale, Won-Seob-Cho Anion Receptor Chemistry
  • A.Imeson, Food Stabilizers, Thickeners and Gelling Agents, 2011.
  • O.R.Fennema, “Food Chemistry” (three chapters), 2012
  • R.J.Whitehurst, M.van Oort, “Enzymes in food technology”, 2013
  • Kirk-Othmer, Chemical Technology of Cosmetics (five chapters), 2016
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